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Canine IL11RA/IL-11RA (His Tag) recombinant protein

Cat.#: 502411

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Product Information

  • Product Name
    Canine IL11RA/IL-11RA (His Tag) recombinant protein
  • Documents
  • Description
    Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.
  • Protein name
    Uncharacterized protein
  • Protein short names
    IL11RA; AI314697; MGC2146; IL11RA2; RP23-167I12.2; IL11RA1; HCG_2011440; IL-11RA; NR1; GP130
  • Uniprot ID
    E2RAD9
  • Gene Name
    IL11RA
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the canine IL11RA (XP_005626799.1) (Met1-Leu363) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Canine
  • Molecular weight
    The recombinant canine IL11RA comprises 352 amino acids and has a predicted molecular mass of 38.4 kDa. The apparent molecular mass of the protein is approximately 47.7 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Canine IL11RA / IL-11RA / IL11R? Protein (His Tag) SDS-PAGE

    Canine IL11RA / IL-11RA / IL11R? Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"