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Product Name
Canine TGF-beta 2 (His Tag) recombinant protein
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Description
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. In addition, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD.
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Protein name
Uncharacterized protein
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Protein short names
TGFB-2; TGFB2; BB105277; TGF-BETA2; TGF-BETA 2; MGC116892
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Uniprot ID
F1PKH0
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Gene Name
TGFB2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the canine TGFB2 (XP_858677.1) (Met1-Ser414) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Canine
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Molecular weight
The recombinant canine TGFB2 consists 405 amino acids and predicts a molecular mass of 47 kDa.
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Purity
> (32+46+17) % as determined by SDS-PAGE.
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Validations
Canine TGFB2 / TGF-beta 2 Protein (His Tag) SDS-PAGE
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