Rhesus CDCP1 (His Tag) recombinant protein
CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and in both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.
Protein short names
CUB DOMAIN-CONTAINING PROTEIN 1; TRASK; TRANSMEMBRANE AND ASSOCIATED WITH SRC KINASES; CD318; MEMBRANE GLYCOPROTEIN GP140; UNQ2486/PRO5773; 9030022E12RIK; E030027H19RIK; SUBTRACTIVE IMMUNIZATION M PLUS HEP3-ASSOCIATED 135 KDA PROTEIN; AA409659; SIMA135
A DNA sequence encoding the rhesus CDCP1 (XP_001114659.1) (Met1-Thr667) was expressed with a polyhistidine tag at the C-terminus.
The recombinant rhesus CDCP1 comprises 649 amino acids and has a calculated molecular mass of 73.4 KDa.
> 95 % as determined by SDS-PAGE
Cynomolgus CDCP1 Protein (His Tag) SDS-PAGE
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