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Product Name
Human UBASH3A (aa 354-623, His Tag) recombinant protein
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Description
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
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Protein name
Ubiquitin-associated and SH3 domain-containing protein A
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Protein short names
STS-2; RP24-261L18.1; TULA; CLIP4; A; C330001M22; UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING A; T-CELL UBIQUITIN LIGAND 1; SUPPRESSOR OF T-CELL RECEPTOR SIGNALING 2; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING PROTEIN A; 5830413C03RIK; T-CELL UBIQUITIN LIGAND PROTEIN; UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING; CBL-INTERACTING PROTEIN 4; TULA-1; UBASH3A
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Uniprot ID
P57075
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Gene Name
UBASH3A; STS2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human UBASH3A (AAH69511.1) (Ala354-Asn623) was expressed with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human UBASH3A consists of 286 amino acids and predicts a molecular mass of 32.2 KDa. It migrates as an approximately 30 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human UBASH3A Protein (aa 354-623, His Tag) SDS-PAGE
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