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Human TPST1 (His Tag) recombinant protein

Cat.#: 501870

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Product Information

  • Product Name
    Human TPST1 (His Tag) recombinant protein
  • Documents
  • Description
    Protein-tyrosine sulfotransferase 1, also known as Tyrosylprotein sulfotransferase 1 and TPST1, is a single-pass type I I membrane protein which belongs to the protein sulfotransferase family. Tyrosine O-sulfation is a common posttranslational modification of proteins in all multicellular organisms. This reaction is mediated by a Golgi enzyme activity called tyrosylprotein sulfotransferase (TPST) that catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to tyrosine residues within acidic motifs of polypeptides. Tyrosine O-sulfation has been shown to be important in protein-protein interactions in several systems. Tyrosine sulfation is mediated by one of two Golgi isoenzymes, called tyrosylprotein sulfotransferases (TPST-1 and TPST-2). A relatively small number of proteins are known to undergo tyrosine sulfation, including certain adhesion molecules, G-protein-coupled receptors, coagulation factors, serpins, extracellular matrix proteins, and hormones. TPST1 is a human tyrosylprotein sulfotransferase that uses 3'phosphoadenosine-5'phosphosulfate (PAPS) to transfer the sulfate moiety to proteins predominantly designated for secretion. TPST1 bears N-linked glycosyl residues exclusively at position Asn60 and Asn262. TPST1 and TPST2 have distinct biological roles that may reflect differences in their macromolecular substrate specificity.
  • Protein name
    Tyrosylprotein sulfotransferase 1, isoform CRA_a
  • Protein short names
    R75054; TANGO13A; TPST-1; TPST1
  • Uniprot ID
    O60507
  • Gene Name
    TPST1; hCG_39437
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human TPST1 (NP_003587.1) extracellular domain (Gln 26-Glu 370) was expressed, with a polyhistidine tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human TPST1 consists of 361 amino acids and has a calculated molecular mass of 41.7 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhTPST1 is approximately 45-48 kDa due to glycosylation.
  • Purity
    > 80 % as determined by SDS-PAGE
  • Validations

    Human TPST1 Protein (His Tag) SDS-PAGE

    Human TPST1 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"