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Product Name
Human PTPN12 (aa 1-355, His & GST Tag) recombinant protein
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Description
Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.
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Protein name
Tyrosine-protein phosphatase non-receptor type 12
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Protein short names
NON-RECEPTOR TYPE 12; TCAG7.1075; PTPG1; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12; MPTP-PEST; PTP-P19; NON-RECEPTOR TYPE 12; PROTEIN-TYROSINE PHOSPHATASE G1; PTPN12; PTP-PEST; P19-PTP; PROTEIN TYROSINE PHOSPHATASE; PROTEIN-TYROSINE PHOSPHATASE P19
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Uniprot ID
Q05209
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Gene Name
PTPN12
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human PTPN12 (AAA36529.1) (Met1-Gln355) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PTPN12 chimera consists of 592 amino acids and has a calculated molecular mass of 69.4 kDa. The recombinant protein migrates approximately 64 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate, R&D Systems, Catalog # ES006.
The specific activity is > 15 μmoles/min/mg. -
Validations
Human PTPN12 Protein (aa 1-355, His & GST Tag) SDS-PAGE
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