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Product Name
Mouse TWSG1 (His Tag) recombinant protein
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Description
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
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Protein name
Twisted gastrulation protein homolog 1
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Protein short names
PSEC0250; TSG; AW552143; D17ERTD403E; TWISTED GASTRULATION PROTEIN HOMOLOG 1; 1810013J15RIK; TWG; 9030422N06RIK
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Uniprot ID
Q9EP52
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Gene Name
Twsg1; Tsg
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse TWSG1 (Q9EP52) (Met 1-Phe 222) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse TWSG1 comprises 209 amino acids and has a calculated molecular mass of 23.6kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 34 kDa in SDS-PAGE under reducing conditions.
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Purity
> 93 % as determined by SDS-PAGE
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Validations
Mouse TWSG1 Protein (His Tag) SDS-PAGE
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