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Human DcR3/TNFRSF6B (Fc Tag) recombinant protein

Cat.#: 502783

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Product Information

  • Product Name
    Human DcR3/TNFRSF6B (Fc Tag) recombinant protein
  • Documents
  • Description
    Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
  • Protein name
    Tumor necrosis factor receptor superfamily member 6B
  • Protein short names
    HCG_2044836; TNFRSF6B; DCR3; TR6; DJ583P15.1.1; M68
  • Uniprot ID
    O95407
  • Gene Name
    TNFRSF6B; DCR3; TR6; UNQ186/PRO212
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human DCR3 (O95407)(Met1-His300) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human DCR3/Fc is a disulfide-linked homodimer. The reduced monomer comprises 508 amino acids and has a predicted molecular mass of 56.4 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to inhibit Fas Ligand induced apoptosis of Jurkat human acute T cell leukemia cells.
    The ED50 for this effect is typically 0.01-0.05 μg/mL in the presence of 20 ng/mL recombinant human Fas Ligand.
  • Validations

    Human DCR3 / TNFRSF6B Protein (Fc Tag) SDS-PAGE

    Human DCR3 / TNFRSF6B Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"