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Product Name
Human CD153/CD30L/TNFSF8 recombinant protein
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Description
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.
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Protein name
Tumor necrosis factor ligand superfamily member 8
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Protein short names
CD30LG; CD153; TNFSF8; MGC138144; CD30L
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Uniprot ID
Q52M88
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Gene Name
TNFSF8; CD30L; CD30LG
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CD30L (NP_001235.1) (Gln63-Asp234) was expressed with two additional amino acids (Gly & Pro ) at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CD30L consists of 172 amino acids and predicts a molecular mass of 19.6 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Human CD153 / CD30L / TNFSF8 Protein
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