Human Fas Ligand / FASLG / CD95L (His Tag) recombinant protein

Human Fas Ligand / FASLG / CD95L (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.

Tumor necrosis factor ligand superfamily member 6

TNFSF6; FASL; FASLG; FAS LIGAND (TNF SUPERFAMILY; APOPTOSIS (APO-1) ANTIGEN LIGAND 1; MEMBER 6; CD95 LIGAND; TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY; APTL; ALPS1B; APT1LG1; CD95L; MEMBER 6); CD95-L; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6; APOPTOSIS ANTIGEN LIGAND; FAS ANTIGEN LIGAND; CD178

Q53ZZ1

FASLG; APT1LG1; CD95L; FASL; TNFSF6

Yeast

A DNA sequence encoding human FASLG (NP_000630.1) (Pro134-Leu281) was expressed with a polyhistidine tag at the N-terminus.

Human

The recombinant human human FASLG consists of 168 amino acids and predicts a molecular mass of 19.3 KDa. It migrates as an approximately 26 KDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA.
1. Immobilized human His-FASLG at 10 μg/ml (100 μl/well) can bind Cynomolgus FAS-Fc (Cat:504216). The EC₅₀ of Cynomolgus FAS-Fc (Cat:504216) is 0.06-0.14 μg/ml.
2. Immobilized human His-FASLG at 10 μg/ml (100 μl/well) can bind rat FAS-Fc (Cat:500940). The EC₅₀ of rat FAS-Fc (Cat:500940) is 0.22-0.52 μg/ml.