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Product Name
TTF1; NKX2-1 antibody
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Description
TTF1; NKX2-1 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, A549 cells. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 41-45 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
BHC antibody; Homeobox protein Nkx 2.1 antibody; NK 2 antibody; NK2 homeobox 1 antibody; NKX2 1 antibody; NKX2.1 antibody; NKX2-1 antibody; NKX2A antibody; TEBP antibody; Thyroid nuclear factor 1 antibody; Thyroid transcription factor 1 antibody; TITF1 antibody; TTF 1 antibody; TTF1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_003317). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:116389(NKX2-1 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:116389(NKX2-1 antibody) at dilution of 1:50 (under 40x lens)
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Background
NKX2-1, also named as NKX2A, TITF1 and TTF1, belongs to the NK-2 homeobox family. It is a transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype. It may play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC), choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD). The antibody is specific to NKX2-1.
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