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Product Name
TTF1 antibody
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Description
TTF1 Mouse Monoclonal antibody. Positive IHC detected in human lung cancer tissue, human liver cancer tissue. Positive WB detected in Hela cells. Observed molecular weight by Western-blot: 41 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
BHC antibody; Homeobox protein Nkx 2.1 antibody; NK 2 antibody; NK2 homeobox 1 antibody; NKX2 1 antibody; NKX2.1 antibody; NKX2-1 antibody; NKX2A antibody; TEBP antibody; Thyroid nuclear factor 1 antibody; Thyroid transcription factor 1 antibody; TITF1 antibody; TTF 1 antibody; TTF1 antibody
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Isotype
Mouse IgG3
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_003317). Purification method: Protein A purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:107649(NKX2-1 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:107649(NKX2-1 antibody) at dilution of 1:50 (under 40x lens)
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Background
Homeobox protein Nkx-2.1 (NKX2-1), also named Thyroid nuclear factor 1,Thyroid transcription factor 1(TTF1). It is a transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC), choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"