TTC37 antibody

TTC37 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TTC37 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human kidney tissue, human tonsillitis tissue. Positive WB detected in HeLa cells, HEK-293 cells, MCF-7 cells, mouse testis tissue. Observed molecular weight by Western-blot: 140-150 kDa

ELISA, WB, IHC, IF

Human, Mouse; other species not tested.

KIAA0372 antibody; TPR repeat protein 37 antibody; TTC37 antibody

Rabbit IgG

This antibody was obtained by immunization of TTC37 recombinant protein (Accession Number: XM_047417937). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

TTC37 (tetratricopeptide repeat protein 37), also named as Thespin, encodes 1,564 amino acid protein that contains twenty tetratricopeptide (TPR) repeats. TPR repeat-containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Although not expressed in liver, TTC37 is a widely expressed protein with highest levels of expression in vascular tissues, lymph node, pituitary, lung and intestine. TTC37 is a component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Defects in TTC37 are associated with Trico-Hepato-Enteric (THE) syndrome.

• Kohda M, Tokuzawa Y, Kishita Y. A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies. PLoS genetics. 12(1):e1005679. 2016.