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Product Name
TSPAN33 antibody
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Description
TSPAN33 Rabbit Polyclonal antibody. Positive IHC detected in human hepat℃irrhosis tissue. Positive WB detected in human brain tissue, human blood tissue. Observed molecular weight by Western-blot: 64-72kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
hPen antibody; PEN antibody; Penumbra antibody; Proerythroblast new membrane antibody; tetraspanin 33 antibody; Tspan 33 antibody; TSPAN33 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TSPAN33 recombinant protein (Accession Number: NM_178562). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:116362(TSPAN33 antibody) at dilution of 1:400
Immunohistochemical of paraffin-embedded human hepatocirrhosis using Catalog No:116362(TSPAN33 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human hepatocirrhosis using Catalog No:116362(TSPAN33 antibody) at dilution of 1:50 (under 40x lens)
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Background
TSPAN33 is a membrane protein of the tetraspanin superfamily, which are characterized by the presence of four conserved transmembrane regions. Tetraspanins have been involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, and cancer. TSPAN33 belongs to the TSPANC8 subfamily, which also include TSPAN5, TSPAN10, TSPAN14, TSPAN15, and TSPAN17. It has been reported that TSPANC8 tetraspanins interact with ADAM10 and have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch receptor activation (PMID: 23091066; 23035126).
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