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Product Name
TRX2 antibody
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Description
TRX2 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue. Positive WB detected in Raji cells, human liver tissue. Observed molecular weight by Western-blot: 12 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
MT TRX antibody; MTRX antibody; Thioredoxin 2 antibody; Thioredoxin antibody; mitOChondrial antibody; TRX2 antibody; TXN2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TRX2 recombinant protein (Accession Number: NM_012473). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:116422(TRX2,TXN2 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:116422(TRX2,TXN2 antibody) at dilution of 1:100 (under 10x lens)
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Background
TXN2(Thioredoxin-2) is also named as TRX2,MTRX,Mt-TRX and regulates the mitochondrial redox state and plays an important role in cell proliferation.It has been shown that cells conditionally deficient in Trx2 undergo apoptosis in the absence of exogenous stress, accompanied by an accumulation of intracellular ROS, the activation of caspase 9 and caspase 3, and the release of cytochrome c into the cytosol.In the retina, the expression profile and the role of Trx2 have not yet been defined(PMID:18441302).
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References
- Brennan LA, Lee W, Kantorow M. TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens. PloS one. 5(11):e15421. 2010.
- Wu H, Xiao Y, Zhang S. The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell reports. 3(5):1663-77. 2013.
- Arodin L, Lamparter H, Karlsson H. Alteration of thioredoxin and glutaredoxin in the progression of Alzheimer's disease. Journal of Alzheimer's disease : JAD. 39(4):787-97. 2014.
- Arodin L, Miranda-Vizuete A, Swoboda P, Fernandes AP. Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death. Free radical biology & medicine. 73:328-36. 2014.
- Aso E, Sánchez-Pla A, Vegas-Lozano E, Maldonado R, Ferrer I. Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice. Journal of Alzheimer's disease : JAD. 43(3):977-91. 2015.
- Brown-Borg HM, Rakoczy S, Wonderlich JA, Armstrong V, Rojanathammanee L. Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice. Longevity & healthspan. 3(1):10. 2014.
- Sun HY, Hu YJ, Zhao XY. Age-related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex. The FEBS journal. 282(14):2758-74. 2015.
- Hou Y, Li S, Wu M. Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy. American journal of physiology. Renal physiology. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"