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Human TRIB3/TRB3 (GST Tag) recombinant protein

Cat.#: 500029

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Product Information

  • Product Name
    Human TRIB3/TRB3 (GST Tag) recombinant protein
  • Documents
  • Description
    Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
  • Protein name
    Tribbles homolog 3
  • Protein short names
    TRB3; C20ORF97; SINK; TRB-3; IFLD2; TRIB3; NIPK; SKIP3; RP23-396N8.1; RP5-1103G7.7
  • Uniprot ID
    Q96RU7
  • Gene Name
    TRIB3; C20orf97; NIPK; SKIP3; TRB3
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human TRIB3 (NP_066981.2) (Met 1-Gly 358) was fused with the GST tag at N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human TRIB3/GST chimera consists of 582 amino acids and predicts a molecular mass of 65.8 kDa as estimated in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Kinase activity untested
  • Validations

    Human TRIB3 / TRB3 Protein (GST Tag) SDS-PAGE

    Human TRIB3 / TRB3 Protein (GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"