Human TFAP2C / AP2-GAMMA (His Tag) recombinant protein

Human TFAP2C / AP2-GAMMA (His Tag) recombinant protein

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Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Transcription factor AP-2 gamma

STIMULATED BY RETINOIC ACID GENE 2; TCFAP2C; RP23-228E2.9; AP2-GAMMA; AA409384; TRANSCRIPTION FACTOR ERF-1; AP-2.2; TRANSCRIPTION FACTOR AP-2 GAMMA (ACTIVATING ENHANCER-BINDING PROTEIN 2 GAMMA); HAP-2G; STRA2; ACTIVATING ENHANCER-BINDING PROTEIN 2 GAMMA; ERF1; TFAP2G; ESTROGEN RECEPTOR FACTOR 1; TRANSCRIPTION FACTOR AP-2 GAMMA; AP2GAMMA

Q92754

TFAP2C

E. coli

A DNA sequence encoding the mature form of human TFAP2C (Q92754) (Leu128-Val223) was expressed with a polyhistide tag at the N-terminus.

Human

The recombinant human TFAP2C consists of 111 amino acids and predicts a molecular mass of 12.3 KDa. It migrates as an approximately 12-14 KDa band in SDS-PAGE under reducing conditions.

> 98 % as determined by SDS-PAGE