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Product Name
Mouse TLR3 / CD283 (His Tag) recombinant protein
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Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity).
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Protein name
Toll-like receptor 3
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Protein short names
TLR3; CD283; AI957183
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Uniprot ID
Q99MB1
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Gene Name
Tlr3
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the soluble form of mouse TLR3 (NP_569054.2) extracellular domain (Cys 29-Leu 705) was fused with a signal peptide at the N-terminus and a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse TLR3 consists of 688 amino acids and has a calculated molecular mass of 78 kDa. The recombinant protein migrates as an approximately 75-80 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Mouse TLR3 / CD283 Protein (His Tag) SDS-PAGE
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