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Product Name
TMSB4X antibody
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Description
TMSB4X Rabbit Polyclonal antibody. Positive WB detected in human skeletal muscle tissue. Observed molecular weight by Western-blot: 5 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
PTMB4 antibody; Seraspenide antibody; T beta 4 antibody; TB4X antibody; THYB4 antibody; Thymosin beta 4 antibody; thymosin beta 4 antibody; X linked antibody; TMSB4 antibody; TMSB4X antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TMSB4X recombinant protein (Accession Number: BC001631). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
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Validations
human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:116280(TMSB4X antibody) at dilution of 1:2000
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Background
Thymosin beta 4 (Tβ4), encoded by TMSB4X gene, is an actin sequestering protein which plays an important role in the organization of the cytoskeleton. Numerous studies have demonstrated the effects of Tβ4 on cell migration, proliferation, apoptosis and inflammation after exogenous treatment (PMID: 22652458). Recently, novel findings provided compelling evidence that Tβ4 played a key role in facilitating tumor metastasis and angiogenesis. It has been found that Tβ4 expressed increasingly in a number of metastatic tumors, thus providing a potential target of opportunity for cancer management, especially for cancer metastasis therapy (PMID: 22856429).
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References
- Zhou Y, Li S, Huang Q, Xie L, Zhu X. Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3. Journal of molecular cell biology. 5(4):239-49. 2013.
- Tanaka K, Fujiya M, Konishi H. Probiotic-derived polyphosphate improves the intestinal barrier function through the caveolin-dependent endocytic pathway. Biochemical and biophysical research communications. 467(3):541-8. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"