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Product Name
TMPRSS6 antibody
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Description
TMPRSS6 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, HepG2 cells, MCF7 cells, mouse liver tissue. Observed molecular weight by Western-blot: 52kd
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
IRIDA antibody; Matriptase 2 antibody; TMPRSS6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TMPRSS6 recombinant protein (Accession Number: NM_153019). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:116278(TMPRSS6 antibody) at dilution of 1:500
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Background
The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism. Upstream of the hepcidin-regulated signaling pathway, TMPRSS6 cleaves its target substrate hemojuvelin (HJV) at the plasma membrane(PMID:21724843).It Belongs to the peptidase S1 family.Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA).It has 4 isoforms produced by alternative splicing.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"