• TKKTLRT peptide

TKKTLRT peptide

Not For Human Use, Lab Use Only.

Cat.#: 319146

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Product Information

  • Product Name
    TKKTLRT peptide
  • Documents
  • Sequence Shortening
    H-TKKTLRT-OH
  • Sequence
    H-Thr-Lys-Lys-Thr-Leu-Arg-Thr-OH
  • Length (aa)
    7
  • Peptide Purity (HPLC)
    95.45%
  • Molecular Formula
    C36H70N12O11
  • Molecular Weight
    847.01
  • Source
    Synthetic
  • Form
    Powder
  • Description
    TKKTLRT is a heptapeptide that belongs to the collagen-binding domain (CBD) family. CBDs are polypeptides that can bind specifically with collagens, which are structural proteins found in various tissues including tumors. The TKKTLRT peptide was designed based on the cleavage site of collagenase enzyme present in type I alpha 2 chain of collagen. It has been shown to have good tissue penetration and binding affinity towards exposed collagens within tumor tissues. When conjugated with therapeutic molecules such as antibodies or fusion proteins, TKKTLRT acts as a homing device for these molecules by targeting them specifically towards tumor cells through its interaction with exposed collagens within the tumor microenvironment. Studies have demonstrated that using TKKTLRT-conjugated therapeutics results in improved retention and efficacy at target sites while reducing off-target effects on normal cells compared to unmodified therapeutics.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Liu J, Meng Z, Xu T, Kuerban K, Wang S, Zhang X, et al. A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer. Front Immunol. 2022
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"