Product Name

Thyroglobulin antibody

Documents

Description

Thyroglobulin Rabbit Polyclonal antibody. Positive IHC detected in human thyroid tissue, human thyroid cancer tissue. Positive WB detected in Transfected HEK-293 cells.

Tested applications

ELISA, WB, IHC

Species reactivity

Human; other species not tested.

Alternative names

AITD3 antibody; TGN antibody; thyroglobulin antibody

Isotype

Rabbit IgG

Preparation

This antibody was obtained by immunization of Thyroglobulin recombinant protein (Accession Number: NM_003235). Purification method: Antigen affinity purified.

Clonality

Polyclonal

Formulation

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions

Store at -20℃. DO NOT ALIQUOT

Applications

Recommended Dilution:

WB: 1:500-1:5000

IHC: 1:50-1:500

Validations

Immunohistochemistry of paraffin-embedded human thyroid tissue slide using Catalog No:116117(TG Antibody) at dilution of 1:200 (under 10x lens).

Immunohistochemistry of paraffin-embedded human thyroid tissue slide using Catalog No:116117(TG Antibody) at dilution of 1:200 (under 40x lens).

Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:116117(TG Antibody) at dilution of 1:1000

Background

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.

Thyroglobulin antibody

Product Information

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