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Product Name
Mouse THSD1 (His Tag) recombinant protein
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Description
Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein which contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. In vitro, nanomolar concentrations of Thrombospondin-1 are required to alter endothelial and vascular smooth muscle cell adhesion, proliferation, motility, and survival. As a major platelet protein, for a long time it was postulated to control hemostasis via platelet aggregate stabilization. THSD1 is a potent angiogenesis inhibitor, and down-regulation of THSD1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types.
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Protein name
Thrombospondin type-1 domain-containing protein 1
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Protein short names
UNQ3010; AW121720; MGC74971; TMTSP; RP11-245D16.1; THSD1; 4833423O18RIK
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Uniprot ID
Q9JM61
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Gene Name
Thsd1; Tmtsp
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse THSD1 (NP_062522.1) (Met 1-Asn 412) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse THSD1 consists of 399 amino acids and has a calculated molecular mass of 45 kDa. As a result of glycosylation, the apparent molecular mass of rm THSD1 is approximately 60-70 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse THSD1 / TMTSP Protein (His Tag) SDS-PAGE
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