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  • tcY-NH2 peptide

tcY-NH2 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319053

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Optional Service: TFA RemovalWhat's this?

Special Price 178.4 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    tcY-NH2 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    trans-Cinnamoyl-YPGKF-NH2
  • Sequence
    trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-N2
  • Length (aa)
    5
  • Peptide Purity (HPLC)
    95.62%
  • Molecular Formula
    C40H49N7O7
  • Molecular Weight
    739.87
  • Source
    Synthetic
  • Form
    Powder
  • Description
    tcY-NH2 is a selective PAR4 antagonist peptide which can block platelet aggregation caused by thrombin, without affecting ADP mediated aggregation. tcY-NH-2 also blocks PAR4 activation of the ERK pathway and through this mechanism can mediate aortic vascular smooth muscle cell migration and proliferation in rat models.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248
    • Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771
    • Peng (2019) Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function. Front. Immunology 10 1311 PMID: 31275306
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

  • Molar Concentration Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"