• TAT-obestatin peptide

TAT-obestatin peptide

Not For Human Use, Lab Use Only.

Cat.#: 319551

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Optional Service: TFA RemovalWhat's this?

Special Price 429.0 USD

Availability: 4 weeks
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Product Information

  • Product Name
    TAT-obestatin peptide
  • Documents
  • Sequence
    H-RKKRRQRRRFNAPFDVGIKLSGVQYQQHSQAL-NH2
  • Three letter code
    H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH2
  • Length (aa)
    32
  • Peptide Purity (HPLC)
    95.88%
  • Molecular Formula
    C169H280N62O43
  • Molecular Weight
    3868.4
  • Source
    Synthetic
  • Additional Information
    Obestatin is a 23-amino-acid peptide originally regarded as an anorexigenic factor. Obestatin is incapable of crossing the blood brain barrier (BBB), which may affect its biological function. TAT-obestatin is composed of TAT (is capable of delivering different types of proteins through the BBB.) and obestatin. TAT-obestatin might play a role in white adipose tissue metabolism, but its physiological effects on food intake and body weight gain regulation remain unclear.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Ren G, He Z, Cong P, Chen H, Guo Y, Yu J, Liu Z, Ji Q, Song Z, Chen Y. Peripheral administration of TAT-obestatin can influence the expression of liporegulatory genes but fails to affect food intake in mice. Peptides. 2013 Apr;42:8-14. doi: 10.1016/j.peptides.2013.01.004. Epub 2013 Jan 9. PMID: 23313740.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"