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  • SV40 NLS peptide

SV40 NLS peptide

Not For Human Use, Lab Use Only.

Cat.#: 310395

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Product Information

  • Product Name
    SV40 NLS peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    PKKKRKVG
  • Sequence
    Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly
  • Length (aa)
    8
  • Peptide Purity (HPLC)
    95.33%
  • Molecular Formula
    C42H81N15O9
  • Molecular Weight
    940.19
  • CAS No.
    95088-49-6
  • Source
    Synthetic
  • Form
    Powder
  • Description
    NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Zanta MA, Belguise-Valladier P, Behr JP. Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6. doi: 10.1073/pnas.96.1.91. PMID: 9874777; PMCID: PMC15098.
    • Cao S, Zhou Q, Chen JL, Jiang N, Wang YJ, Deng Q, Hu B, Guo RQ. Enhanced effect of nuclear localization signal peptide during ultrasound‑targeted microbubble destruction‑mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572. doi: 10.3892/mmr.2017.6661. Epub 2017 May 31. PMID: 28586046; PMCID: PMC5482142.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"