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Product Name
Human STIM1 (His Tag) recombinant protein
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Description
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
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Protein name
Stromal interaction molecule 1
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Protein short names
IMD10; STRMK; GOK; STIM1; D11S4896E; SIM; TAM; TAM1
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Uniprot ID
Q13586
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Gene Name
STIM1; GOK
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human STIM1 (NP_003147.2) extracellular domain (Met 1-Asp 213) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human STIM1 consists of 202 amino acids and predictes a molecular mass of 23.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh STIM1 is approximately 33-38 kDa due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human STIM1 / GOK Protein (His Tag) SDS-PAGE
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