Stigmurin peptide
Not For Human Use, Lab Use Only.
Cat.#: 311267
Special Price 215.0 USD
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Product Name
Stigmurin peptide
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Sequence Shortening
FFSLIPSLVGGLISAFK
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Sequence
Phe-Phe-Ser-Leu-Ile-Pro-Ser-Leu-Val-Gly-Gly-Leu-Ile-Ser-Ala-Phe-Lys
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Length (aa)
17
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Peptide Purity (HPLC)
96.9%
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Source
Synthetic
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Form
Powder
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Description
APD analysis reveals that the sequence is 88.2% similar to scorpion AMP TsAP-1. Active against S. aureus ATCC 29213 (MIC 8.7 uM), MRSA ATCC 33591 (MIC 17.4 uM), yeasts C. albicans ATCC 90028 (MIC 34.8 uM), C. krusei ATCC 6258, and C. glabrata ATCC 90030 (MIC 69.5 uM). ~50% killing of SiHa cells between 70-140 uM and of Vero E6 cells at ~140 uM. CD curves are helical in TFE. The source of Stigmurin is venom gland, Tityus stigmurus.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- De melo ET, Estrela AB, Santos EC, et al. Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin. Peptides. 2015;
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
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• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"