SP94 peptide
Not For Human Use, Lab Use Only.
Cat.#: 319470
Special Price 101.9 USD
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Product Name
SP94 peptide
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Sequence Shortening
H-SFSIIHTPILPL-OH
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Sequence
H-Ser-Phe-Ser-Ile-Ile-His-Thr-Pro-Ile-Leu-Pro-Leu-OH
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Length (aa)
12
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Peptide Purity (HPLC)
95.52%
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Molecular Formula
C65H104N14O16
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Molecular Weight
1337.6
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Source
Synthetic
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Form
Powder
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Description
SP94 (SFSIIHTPILPL), a novel peptide identified by Lo et al. using a phage display technique, can specifically bind to various types of HCC cells, such as HepG2 and Huh-7. HCC cell membrane expresses an unknown target molecule that can be recognized by SP94 but not by hepatocytes.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Lo A., Lin C. T. & Wu H. C. Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery. Mol Cancer Ther 7, 579-589 (2008).
- Toita R. et al. A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells. Chem Commun (Camb) 49, 7442-7444 (2013).
- Toita R. et al. Development of human hepatocellular carcinoma cell-targeted protein cages. Bioconjug Chem 23, 1494-1501 (2012).
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"