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Product Name
Human CD150 / SLAM / SLAMF1 (His Tag) recombinant protein
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Description
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
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Protein name
Signaling lymphocytic activation molecule
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Protein short names
SLAM; SLAMF1; MGC151476; AA177906; CD150; CDW150; IPO-3; ESTM51; 4933415F16; MGC151472
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Uniprot ID
Q13291
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Gene Name
SLAMF1; SLAM
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human SLAM (NP_003028.1) precursor (Met 1-Pro 258) with a C-terminal polyhistidine tag was expressed.
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Protein Species
Human
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Molecular weight
The secreted recombinant human SLAM comprises 228 amino acids with a predicted molecular mass of 25.8 kDa. As a result of glycosylation, it migrates as an approximately 45-50 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.
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Validations
Human CD150 / SLAM / SLAMF1 Protein (His Tag) SDS-PAGE
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