Cynomolgus SIRPG/SIRP gamma/CD172g (Fc Tag) recombinant protein

Cynomolgus SIRPG/SIRP gamma/CD172g (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. This cytokine is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG is primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

Signal-regulatory protein gamma

RP11-77C3.2; CD172G; SIRPGAMMA; SIRPB2; SIRP GAMMA; FLJ42230; SIRP-B2; SIRPG; BA77C3.1

G7PGS5

EGM_02249

Human Cells

A DNA sequence encoding the cynomolgus SIRPG (G7PGS5) (Met1-His360) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus SIRPG is a disulfide-linked homodimer. The reduced monomer comprises 573 amino acids and has a calculated molecular mass of 63.6 KDa.The apparent molecular mass of the protein is approximately 69-79 KDa respectively in SDS-PAGE.

> 90 % as determined by SDS-PAGE