SHBG141–161 peptide

SHBG141–161 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-IALGGLLFPASNLRLPLVPAL-OH

H-Ile-Ala-Leu-Gly-Gly-Leu-Leu-Phe-Pro-Ala-Ser-Asn-Leu-Arg-Leu-Pro-Leu-Val-Pro-Ala-Leu-OH

21

95.72%

C₁₀₃H₁₇₃N₂₅O₂₄

2145.62

Synthetic

Powder

SHBG141–161 is a peptide corresponding to amino acids 141–161 of sex hormone binding globulin (SHBG), the loop region of SHBG connecting β-strands 11 and 12. SHBG141–161 is an agonist of the class C orphan G protein coupled receptor GPRC6A, a major regulator of energy metabolism and male fertility, and SHBG141-161 competes for binding to it with its endogenous ligand undercarboxylated osteocalcin (ucOCN). In vitro, SHBG141-161 stimulates insulin secretion from β-cells and also the production and release of testosterone from Leydig and Langerhans β-cells cell lines.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• De Toni et al (2019) SHBG141-161 Domain-Peptide Stimulates GPRC6A-Mediated Response in Leydig and β-Langerhans cell lines. Sci Rep. 9(1) 19432 PMID: 31857654

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.