• sGnRH-A peptide

sGnRH-A peptide

Not For Human Use, Lab Use Only.

Cat.#: 319686

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Product Information

  • Product Name
    sGnRH-A peptide
  • Documents
  • Sequence Shortening
    Pyr-HWSYrWLP-NHEt, r=D-Arg
  • Sequence
    Pyr-His-Trp-Ser-Tyr-D-Arg-Trp-Leu-Pro-NHEt
  • Length (aa)
    8
  • Peptide Purity (HPLC)
    95.74%
  • Molecular Formula
    C64H83N17O12
  • Molecular Weight
    1282.45
  • CAS No.
    96497-82-4
  • PubChem CID
    121493629
  • Source
    Synthetic
  • Form
    Powder
  • Description
    sGnRH-A ([D-Arg⁶, Pro⁹]-LHRH) is a synthetic analog of gonadotropin-releasing hormone (GnRH). sGnRH-A can elevate the GH mRNA level and stimulate the GH secretion in common carp pituitary fragments in a dose-dependent manner. Compared to other GnRHs and its analogs, it shows a higher potency in increasing the GH mRNA level and GH release. In a time-course experiment, its function on GH secretion was observed after 6 h incubation, while its effect on the GH mRNA level was noted after 12 h treatment. Among mammalian GnRH, avian GnRH, and piscine GnRH, sGnRH and sGnRH-A showed the highest potency in increasing GH mRNA level and GH release, followed by cGnRH-II ([His⁵, Tyr⁸]-LHRH), and finally LHRH and LHRH-A ([D-Trp⁶, Pro⁹]-LHRH).
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Li WS, Lin HR, Wong AO. Effects of gonadotropin-releasing hormone on growth hormone secretion and gene expression in common carp pituitary. Comp Biochem Physiol B Biochem Mol Biol. 2002 Jun;132(2):335-41. doi: 10.1016/s1096-4959(02)00039-8. PMID: 12031458.
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"