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Product Name
Rat (His Tag) recombinant protein
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Description
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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Protein name
Serotransferrin
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Protein short names
TF; TRANSFERRIN; SIDEROPHILIN; DKFZP781D0156; PRO1557; PRO2086; SEROTRANSFERRIN; BETA-1 METAL-BINDING GLOBULIN
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Uniprot ID
P12346
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Gene Name
Tf
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat TF (NP_001013128.1) (Met1-Ser698) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat TF comprises 690 amino acids and predicts a molecular mass of 76 kDa. The apparent molecular mass of the recombinant protein is approximately 89 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083.
The ED50 for this effect is typically 0.02-1 μg/mL. -
Validations
Rat Transferrin / TF Protein (His Tag) SDS-PAGE
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