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Product Name
Human SGK3/SGKL (His & GST Tag) recombinant protein
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Description
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
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Protein name
Serine/threonine-protein kinase Sgk3
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Protein short names
SGK3; SGK2; CISK; 2510015P22RIK; FZ; SGKL; A330005P07RIK; FY; DKFZP781N0293
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Uniprot ID
Q96BR1
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Gene Name
SGK3; CISK; SGKL
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human SGK3 (Q96BR1-1) (Met 1-Leu 496) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SGK3/GST chimera consists of 733 amino acids and has a calculated molecular mass of 85 kDa. It migrates as an approximately 68 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 96 % as determined by SDS-PAGE
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Activity
No Kinase Activity
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Validations
Human SGK3 / SGKL Protein (His & GST Tag) SDS-PAGE
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