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Product Name
Human STK24 (His Tag) recombinant protein
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Description
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
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Protein name
Serine/threonine-protein kinase 24
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Protein short names
MST3; RP11-111L24.5; 810013H02RIK; HEL-S-95; 1810013H02RIK; MST3B; C76483; MST-3; MGC6330; STE20; STK3
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Uniprot ID
Q9Y6E0
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Gene Name
STK24; MST3; STK3
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human STK24 isoform A (Q9Y6E0-2) (Met 1-His 431) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human STK24 consists of 450 amino acids and predicts a molecular mass of 50.3 kDa. It migrates as an approximately 55 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 82 % as determined by SDS-PAGE
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Activity
The specific activity was determined to be 62 nmol/min/mg using synthetic PKCtide peptide (ERMRPRKRQGSVRRRV) as substrate.
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Validations
Human STK24 / MST3 Protein (His Tag) SDS-PAGE
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