Human STK24 (His Tag) recombinant protein

Cat.#: 502149

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Product Information

  • Product Name
    Human STK24 (His Tag) recombinant protein
  • Documents
  • Description
    Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
  • Protein name
    Serine/threonine-protein kinase 24
  • Protein short names
    MST3; RP11-111L24.5; 810013H02RIK; HEL-S-95; 1810013H02RIK; MST3B; C76483; MST-3; MGC6330; STE20; STK3
  • Uniprot ID
    Q9Y6E0
  • Gene Name
    STK24; MST3; STK3
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human STK24 isoform A (Q9Y6E0-2) (Met 1-His 431) was expressed, with a polyhistidine tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human STK24 consists of 450 amino acids and predicts a molecular mass of 50.3 kDa. It migrates as an approximately 55 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 82 % as determined by SDS-PAGE
  • Activity
    The specific activity was determined to be 62 nmol/min/mg using synthetic PKCtide peptide (ERMRPRKRQGSVRRRV) as substrate.
  • Validations

    Human STK24 / MST3 Protein (His Tag) SDS-PAGE

    Human STK24 / MST3 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"