• self-assembling P11-4 peptide

self-assembling P11-4 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319744

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Product Information

  • Product Name
    self-assembling P11-4 peptide
  • Documents
  • Sequence Shortening
    Ac-QQRFEWEFEQQ-NH2
  • Sequence
    Ac-Gln-Gln-Arg-Phe-Glu-Trp-Glu-Phe-Glu-Gln-Gln-NH2
  • Length (aa)
    11
  • Peptide Purity (HPLC)
    95.19%
  • Molecular Formula
    C72H98N20O22
  • Molecular Weight
    1595.66
  • Source
    Synthetic
  • Form
    Powder
  • Description
    • QQRFEWEFEQQ polypeptide is a rationally designed self-assembling peptide. This polypeptide is known for its ability to form β-sheet complexes and self-assemble into 3-dimensional fibrillar scaffolds. It can interact with collagen type I fibers, as demonstrated by atomic force microscopy and surface plasmon resonance analyses. The interaction leads to an increase in the width of collagen fibers, which in turn may enhance the resistance of collagen to proteolysis.
    • QQRFEWEFEQQ polypeptide also shows promise in dental applications, such as improving the microtensile bonding strength of the bonding interface to artificial caries-affected dentin and decreasing proteolytic activity. It has the potential to contribute to the formation of a more stable hybrid layer with reduced porosity. Overall, this polypeptide offers interesting possibilities for various biomedical and dental applications.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • de Sousa JP, Carvalho RG, Barbosa-Martins LF, Torquato RJS, Mugnol KCU, Nascimento FD, Tersariol ILS, Puppin-Rontani RM. The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin. J Dent Res. 2019 Mar;98(3):347-354. doi: 10.1177/0022034518817351. Epub 2019 Jan 5. PMID: 30612505.
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"