SARS CoV Spike glycoprotein/SARS (Receptor Binding Domain, His Tag)

Cat.#: 504183

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Product Information

  • Product Name
    SARS CoV Spike glycoprotein/SARS (Receptor Binding Domain, His Tag)
  • Documents
  • Description
    The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. 
  • Protein name
    Spike glycoprotein S
  • Uniprot ID
    Q5DIC5
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the receptor binding domain (RBD) of human SARS coronavirus (isolate:WH20) spike (AAX16192.1) (Arg306-Phe527) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    SARS
  • Molecular weight
    The recombinant receptor binding domain (RBD) of human SARS coronavirus (isolate:WH20) spike comprises 233 amino acids and has a predicted molecular mass of 26.5 kDa. The apparent molecular mass of the protein is approximately 35.1 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human SARS Coronavirus Spike Protein (Receptor Binding Domain, His Tag) SDS-PAGE

    Human SARS Coronavirus Spike Protein (Receptor Binding Domain, His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"