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  • Saralasin peptide

Saralasin peptide

Not For Human Use, Lab Use Only.

Cat.#: 319044

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Optional Service: TFA RemovalWhat's this?

Special Price 178.6 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Saralasin peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    XRVYVHPA, X = Sarcosine
  • Sequence
    Sar-Arg-Val-Tyr-Val-His-Pro-Ala-OH
  • Length (aa)
    7
  • Peptide Purity (HPLC)
    95.62%
  • Molecular Formula
    C42H65N13O10
  • Molecular Weight
    912.0
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Saralasin, also known as [Sar1,Val5, Ala8] angiotensin II is an angiotensin II analog with substitutions to the angiotensin II sequence of sarcosine at position 1, valine at position 5,and alanine at position 8. Saralasin is a partial agonist of the angiotensin II receptor, and is used to treat hypertension.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Steinhausen et al (1986) Angiotensin II control of the renal microcirculation: effect of blockade by saralasin. Kidney Int. 30 56 PMID: 3747343
    • Thomas et al (1995) Saralasin suppresses arrhythmias in an isolated guinea-pig ventricular free wall model of simulated ischemia and reperfusion. J.Pharmacol.Exp.Ther. 274 1379 PMID: 7562511
    • Guimond et al (2014) Saralasin and Sarile Are AT2 Receptor Agonists. ACS Med. Chem. Lett. 5(10) 1129 PMID: 25313325
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"