Sarafotoxin S6c/SXS6c peptide

Sarafotoxin S6c/SXS6c peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-CTCNDMTDEECLNFCHQDVIW-OH

H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH

21

95.9%

C₁₀₃H₁₄₇N₂₇O₃₇S₅

2515.74

121695-87-2

254764411

Synthetic

Powder

Sarafotoxin S6c (SXS6c) is a potent vasoconstrictor peptide that belongs to the sarafotoxin family, which is derived from the venom of certain snake species, particularly the African mamba. SXS6c primarily acts as an agonist for the endothelin B (ETB) receptor, although it has some affinity for endothelin A (ETA) receptors as well. This interaction leads to vasoconstriction, which is the narrowing of blood vessels, resulting in increased blood pressure. SXS6c is often used in pharmacological studies to investigate the role of endothelin receptors in vascular physiology and pathophysiology, particularly in conditions such as pulmonary hypertension. It helps researchers understand how endothelin signaling contributes to vascular tone and blood pressure regulation.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• MacLean MR, McCulloch KM, Baird M. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries. J Cardiovasc Pharmacol. 1995 Nov;26(5):822-30. doi: 10.1097/00005344-199511000-00020. PMID: 8637198.

Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.