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Product Name
Recombinant S10AE protein (His tag)
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Description
Recombinant Human Protein S100-A14 (S100 calcium-binding protein A14) fragment encompassing amino acids 1-104, designed to include the complete EF-hand domain. This high-purity protein is an essential tool for investigating the role of S100A14 in modulating P53/TP53 levels, regulating cell survival, apoptosis, and migration, making it ideal for functional assays and mechanistic studies.
Protein S100-A14, encoded by the S100A14 gene, is a multifunctional regulator that modulates P53/TP53 protein levels, influencing critical cellular processes such as cell survival, apoptosis, and proliferation. Depending on the context, it can promote either cell growth or programmed cell death. Additionally, it plays a role in cell migration by regulating the levels of MMP2, a matrix protease under P53/TP53 transcriptional control. Notably, this protein does not bind calcium and is primarily localized in the cytoplasm, as supported by experimental evidence. The provided recombinant fragment spans the full-length EF-h
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Protein name
Protein S100-A14
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Uniprot ID
Q9HCY8
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Gene Name
S100A14; S100A15
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-104 aa (Q9HCY8) were fused with C-terminal 6His tag.
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Sequence
MGQCRSANAE DAQEFSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV TQQLPHLMPS NCGLEEKIAN LGSCNDSKLE FRSFWELIGE AAKSVKLERP VRGHLEHHHH HH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 12.71 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant S10AE protein (His tag) SDS-PAGE
M: Marker; Lane 1: S10AE; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"