S-PE peptide

S-PE peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

1 Vial

Acetylation-PCRFFESHVA-OH

Acetylation-Pro-Cys-Arg-Phe-Phe-Glu-Ser-His-Val-Ala-OH

10

95.43

C₅₆H₇₉N₁₅O₁₅S

1234.38

Synthetic

S-PE is a peptide(sequence: PCRFFESHVA) with active stem cell recruitment capacity. S-PE was screened and identified on Discovery Studio software through peptide display techniques. S-PE showed a outstanding cell homing effect with bone marrow mesenchymal stem cells (BMSCs), as well as promoted osteogenic differentiation to some extent, since S-PE is a promising target peptides simulating the functional domain of stromal cell-derived factor-1 (SDF-1).

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Zhi Peng, Shiwei Niu, Li Gui, Xiaolin Kuang, Fan Li, Bo Chen, Wanting Li, Jianlin Jiao, Sheng Lu, Di Lu, Wnt3a loaded deformable hydrogel acts as a 3D culture platform for in situ recruitment of stem cells to efficiently repair bone defects via the asymmetric division, Chemical Engineering Journal, Volume 442, Part 1, 2022, 136163, ISSN 1385-8947, https://doi.org/10.1016/j.cej.2022.136163.

Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

TFA Removal Service is recommended for:

• Peptides that will be used in cellular assays
• Peptides that will be used as APIs or in manufactured products
• For hydrophilic peptides containing numerous basic residues