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Ryanodine Receptor 2 antibody

Cat.#: 114949

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Special Price 239.0 USD

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Product Information

  • Product Name
    Ryanodine Receptor 2 antibody
  • Documents
  • Description
    Ryanodine Receptor 2 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, human brain tissue, human placenta tissue, mouse brain tissue. Positive IHC detected in human heart tissue, human brain tissue, human placenta tissue, human skeletal muscle tissue. Observed molecular weight by Western-blot: 240-250 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    ARVC2 antibody; ARVD2 antibody; Ryanodine Receptor 2 antibody; ryanodine receptor 2 (cardiac) antibody; ryanodine receptor 2 antibody; cardiac antibody; RYR2 antibody; VTSIP antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_001035). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:50-1:500

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114949(RYR2 antibody) at dilution of 1:500

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114949(RYR2 antibody) at dilution of 1:500

    Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:114949(RYR2 Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:114949(RYR2 Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:114949(RYR2 Antibody) at dilution of 1:200 (under 40x lens).

    Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:114949(RYR2 Antibody) at dilution of 1:200 (under 40x lens).

  • Background
    RYR2 belongs to the ryanodine receptor family. RYR2 provides communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Defects in RYR2 are the cause of familial arrhythmogenic right ventricular dysplasia type 2 (ARVD2) which known as arrhythmogenic right ventricular cardiomyopathy 2 (ARVC2). Defects in RYR2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) which known as stress-induced polymorphic ventricular tachycardia (VTSIP).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"