• RVG15 peptide

RVG15 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319564

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Optional Service: TFA RemovalWhat's this?

Special Price 152.9 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    RVG15 peptide
  • Documents
  • Sequence
    H-YTIWCDIFTDSRQKR-OH
  • Three letter code
    H-Tyr-Thr-Ile-Trp-Cys-Asp-Ile-Phe-Thr-Asp-Ser-Arg-Gln-Lys-Arg-OH
  • Length (aa)
    15
  • Peptide Purity (HPLC)
    95.24%
  • Molecular Formula
    C86H130N24O25S
  • Molecular Weight
    1932.15
  • Source
    Synthetic
  • Additional Information
    RVG15 is a derivative peptide of the rabies virus glycoprotein (RVG). It is known for its ability to bind specifically to the nicotinic acetylcholine receptor (nAChR), which is widely overexpressed on the blood-brain barrier (BBB) and glioma cells. This property of RVG15 is utilized to facilitate the delivery of drugs across the BBB, thereby enhancing their accumulation in brain tumors like glioma.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Xin X, Liu W, Zhang ZA, Han Y, Qi LL, Zhang YY, Zhang XT, Duan HX, Chen LQ, Jin MJ, Wang QM, Gao ZG, Huang W. Efficient Anti-Glioma Therapy Through the Brain-Targeted RVG15-Modified Liposomes Loading Paclitaxel-Cholesterol Complex. Int J Nanomedicine. 2021 Aug 24;16:5755-5776. doi: 10.2147/IJN.S318266. PMID: 34471351; PMCID: PMC8403987.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"