RVG15 peptide
Not For Human Use, Lab Use Only.
Cat.#: 319564
Special Price 152.9 USD
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Product Name
RVG15 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-YTIWCDIFTDSRQKR-OH
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Sequence
H-Tyr-Thr-Ile-Trp-Cys-Asp-Ile-Phe-Thr-Asp-Ser-Arg-Gln-Lys-Arg-OH
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Length (aa)
15
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Peptide Purity (HPLC)
95.24%
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Molecular Formula
C86H130N24O25S
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Molecular Weight
1932.15
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Source
Synthetic
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Form
Powder
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Description
RVG15 is a derivative peptide of the rabies virus glycoprotein (RVG). It is known for its ability to bind specifically to the nicotinic acetylcholine receptor (nAChR), which is widely overexpressed on the blood-brain barrier (BBB) and glioma cells. This property of RVG15 is utilized to facilitate the delivery of drugs across the BBB, thereby enhancing their accumulation in brain tumors like glioma.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Xin X, Liu W, Zhang ZA, Han Y, Qi LL, Zhang YY, Zhang XT, Duan HX, Chen LQ, Jin MJ, Wang QM, Gao ZG, Huang W. Efficient Anti-Glioma Therapy Through the Brain-Targeted RVG15-Modified Liposomes Loading Paclitaxel-Cholesterol Complex. Int J Nanomedicine. 2021 Aug 24;16:5755-5776. doi: 10.2147/IJN.S318266. PMID: 34471351; PMCID: PMC8403987.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"