RTDLDSLRTYTL peptide
Not For Human Use, Lab Use Only.
Cat.#: 319039
Special Price 117.7 USD
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Product Name
RTDLDSLRTYTL peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-RTDLDSLRTYTL-OH
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Sequence
H-Arg-Thr-Asp-Leu-Asp-Ser-Leu-Arg-Thr-Tyr-Thr-Leu-OH
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Length (aa)
12
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Peptide Purity (HPLC)
95.29%
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Molecular Formula
C62H104N18O22
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Molecular Weight
1453.59
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Source
Synthetic
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Form
Powder
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Description
RTDLDSLRTYTL is a phage library selected high affinity 12-mer peptide with high selectivity for alpha(v) beta(6) integrin (avb6). RTDLDSLRTYTL is a selective inhibitor of RGD dependent ligand binding to avb6 in isolated receptor assays with an IC50 of 20 nM, and also in cell adhesion assays with an IC50 of 50 mM. When tested against avb6 binding to immobilized fibronectin, RTDLDSLRTYTL peptide strongly inhibits the avb6 fibronectin interaction with an IC50 of 100 nM. avb6 is a specific receptor for fibronectin which supports epithelial cell proliferation during wound healing and carcinoma progression.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Kraft et al (1999) Definition of an unexpected ligand recognition motif for alphav beta6 integrin. J. Biol. Chem. 274(4) 1979 PMID: 9890954
- Pameijer et al (2007) Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T cell antigen receptor. Can. Gene Ther. 14 91 PMID: 17024231
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"