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  • Rp-1 peptide

Rp-1 peptide

Not For Human Use, Lab Use Only.

Cat.#: 300765

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Optional Service: TFA RemovalWhat's this?

Special Price 227.7 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Rp-1 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-ALYKKFKKKLLKSLKRLG-OH
  • Sequence
    H-Ala-Leu-Tyr-Lys-Lys-Phe-Lys-Lys-Lys-Leu-Leu-Lys-Ser-Leu-Lys-Arg-Leu-Gly-OH
  • Length (aa)
    18
  • Peptide Purity (HPLC)
    96.6%
  • Molecular Formula
    C104H184N28O21
  • Molecular Weight
    2162.74
  • Source
    Synthetic
  • Form
    Powder
  • Description
    RP-1 is an 18-amino-acid peptide modeled in part upon α-helical C-terminal microbicidal domains of mammalian CXCL4 kinocidins. RP-1 has some structural similarities with the antimicrobial peptide C18G. RP-1 is an antimicrobial peptide, and is active against S. aureus, S. typhimurium, E. coli, and C. albicans.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Erfe MC, David CV, Huang C, Lu V, Maretti-Mira AC, Haskell J, Bruhn KW, Yeaman MR, Craft N. Efficacy of synthetic peptides RP-1 and AA-RP-1 against Leishmania species in vitro and in vivo. Antimicrob Agents Chemother. 2012 Feb;56(2):658-65. doi: 10.1128/AAC.05349-11. Epub 2011 Nov 28. PMID: 22123683; PMCID: PMC3264259.
    • Yeaman MR, Gank KD, Bayer AS, Brass EP. Synthetic peptides that exert antimicrobial activities in whole blood and blood-derived matrices. Antimicrob Agents Chemother. 2002 Dec;46(12):3883-91. doi: 10.1128/AAC.46.12.3883-3891.2002. PMID: 12435692; PMCID: PMC132762.
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"