Rothein 2.1 peptide
Not For Human Use, Lab Use Only.
Cat.#: 300054
Special Price 215.2 USD
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Product Name
Rothein 2.1 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-AGGLDDLLEPVLNSADNLVHGL-OH
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Sequence
H-Ala-Gly-Gly-Leu-Asp-Asp-Leu-Leu-Glu-Pro-Val-Leu-Asn-Ser-Ala-Asp-Asn-Leu-Val-His-Gly-Leu-OH
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Length (aa)
22
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Peptide Purity (HPLC)
95.7%
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Molecular Formula
C97H158N26O34
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Molecular Weight
2232.43
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Source
Synthetic
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Form
Powder
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Description
Rothein 2.1 is a peptide found in the skin secretion of the Roth's tree frog Litoria rothii.
It is part of a series of new peptides identified in the secretion, along with Rothein 1 and Rothein 3.
Rothein 2.1 is classified as an inactive peptide, meaning it does not exhibit antimicrobial or neuronal nitric oxide synthase (nNOS) activity. -
Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Brinkworth CS, Bowie JH, Bilusich D, Tyler MJ. The rothein peptides from the skin secretion of Roth's tree frog Litoria rothii. Sequence determination using positive and negative ion electrospray mass spectrometry. Rapid Commun Mass Spectrom. 2005;19(18):2716-24.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"