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Product Name
Human RRM2B/P53R2 (His Tag) recombinant protein
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Description
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
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Protein name
Ribonucleoside-diphosphate reductase subunit M2 B
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Protein short names
MGC102856; DKFZP686M05248; MGC42116; P53R2; MTDPS8A; MTDPS8B
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Uniprot ID
Q7LG56
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Gene Name
RRM2B; P53R2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human RRM2B (Q7LG56-1) (Met 1-Phe 351) was expressed, with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human RRM2B consisting of 366 amino acids and has a calculated molecular mass of 42.6 kDa. It migrates as a 43 kDa band in SDS-PAGE under reducing conditions as predicted.
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Purity
> 92 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind TP53 in a functional ELISA.
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Validations
Human RRM2B / P53R2 Protein (His Tag) SDS-PAGE
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