Rhesus TRAIL R4/CD264/TNFRSF10D (Fc Tag) recombinant protein

Rhesus TRAIL R4/CD264/TNFRSF10D (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.

Uncharacterized protein

TRUNDD; CD264; DCR2; TRAILR4; TRAIL R4; TRAIL-R4

F6TP11

TNFRSF10D

Human Cells

A DNA sequence encoding the rhesus TNFRSF10D (XP_001107922.1) (Met1-Leu206) was expressed with the Fc region of human IgG1 at the C-terminus.

Rhesus

The recombinant rhesus TNFRSF10D comprises 392 amino acids and has a calculated molecular mass of 42.9 KDa.

> 90 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA.
Immobilized Rhesus TNFSF10 (Cat:501168) at 10 μg/ml (100 μl/well) can bind Rhesus TNFRSF10D-Fc, The EC₅₀ of Rhesus TNFRSF10D-Fc is 7.8-18.1 ng/ml.