Rhesus OX40/CD134 (Fc Tag) recombinant protein

Rhesus OX40/CD134 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.

TXGP1L; CD134; TNFRSF4; TXGP1; IMD16; ACT35; RP5-902P8.3; LY-70; OX40

F7CX86

Human Cells

A DNA sequence encoding the rhesus TNFRSF4 (XP_001090870.1) (Met1-Ala216) was expressed with the Fc region of human IgG1 at the C-terminus.

Rhesus

The recombinant rhesus TNFRSF4 consists of 426 amino acids and predicts a molecular mass of 47 kDa.

> 90 % as determined by SDS-PAGE.